SrasV1, Main, Exploration, bibRecord, 005317

Host nutritional status: the neglected virulence factor.

Identifieur interne : 005317 ( Main/Exploration ); précédent : 005316; suivant : 005318

Host nutritional status: the neglected virulence factor.

Auteurs : Melinda A. Beck [États-Unis] ; Jean Handy ; Orville A. Levander

Source :

Trends in microbiology [ 0966-842X ] ; 2004.

RBID : pubmed:15337163

Descripteurs français

KwdFr :
- Animaux, Cardiomyopathies (étiologie), Carence en vitamine E (), Enterovirus (génétique), Enterovirus (pathogénicité), Grippe humaine (étiologie), Génome viral, Humains, Infections à VIH (étiologie), Infections à virus coxsackie (étiologie), Maladies virales (étiologie), Modèles animaux de maladie humaine, Mutation, Poliomyélite (étiologie), Stress oxydatif, Surcharge en fer (), Sélénium (déficit), Virulence, Virus de la grippe A (pathogénicité), État nutritionnel.
MESH :
- déficit : Sélénium.
- génétique : Enterovirus.
- pathogénicité : Enterovirus, Virus de la grippe A.
- étiologie : Cardiomyopathies, Grippe humaine, Infections à VIH, Infections à virus coxsackie, Maladies virales, Poliomyélite.
- Animaux, Carence en vitamine E, Génome viral, Humains, Modèles animaux de maladie humaine, Mutation, Stress oxydatif, Surcharge en fer, Virulence, État nutritionnel.

English descriptors

KwdEn :
- Animals, Cardiomyopathies (etiology), Coxsackievirus Infections (etiology), Disease Models, Animal, Enterovirus (genetics), Enterovirus (pathogenicity), Genome, Viral, HIV Infections (etiology), Humans, Influenza A virus (pathogenicity), Influenza, Human (etiology), Iron Overload (complications), Mutation, Nutritional Status, Oxidative Stress, Poliomyelitis (etiology), Selenium (deficiency), Virulence, Virus Diseases (etiology), Vitamin E Deficiency (complications).
MESH :
- chemical , deficiency : Selenium.
- complications : Iron Overload, Vitamin E Deficiency.
- etiology : Cardiomyopathies, Coxsackievirus Infections, HIV Infections, Influenza, Human, Poliomyelitis, Virus Diseases.
- genetics : Enterovirus.
- pathogenicity : Enterovirus, Influenza A virus.
- Animals, Disease Models, Animal, Genome, Viral, Humans, Mutation, Nutritional Status, Oxidative Stress, Virulence.

Abstract

The emergence of new infectious diseases and old diseases with new pathogenic properties is a burgeoning worldwide problem. Severe acute respiratory syndrome (SARS) and acquired immune deficiency syndrome (AIDS) are just two of the most widely reported recent emerging infectious diseases. What are the factors that contribute to the rapid evolution of viral species? Various hypotheses have been proposed, all involving opportunities for virus spread (for example, agricultural practices, climate changes, rainforest clearing or air travel). However, the nutritional status of the host, until recently, has not been considered a contributing factor to the emergence of infectious disease. In this review, we show that host nutritional status can influence not only the host response to the pathogen, but can also influence the genetic make-up of the viral genome. This latter finding markedly changes our concept of host-pathogen interactions and creates a new paradigm for the study of such phenomena.

DOI: 10.1016/j.tim.2004.07.007
PubMed: 15337163

Affiliations:

Le document en format XML

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<term>Enterovirus (pathogenicity)</term>
<term>Genome, Viral</term>
<term>HIV Infections (etiology)</term>
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<term>Influenza A virus (pathogenicity)</term>
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<term>Poliomyelitis (etiology)</term>
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<front><div type="abstract" xml:lang="en">The emergence of new infectious diseases and old diseases with new pathogenic properties is a burgeoning worldwide problem. Severe acute respiratory syndrome (SARS) and acquired immune deficiency syndrome (AIDS) are just two of the most widely reported recent emerging infectious diseases. What are the factors that contribute to the rapid evolution of viral species? Various hypotheses have been proposed, all involving opportunities for virus spread (for example, agricultural practices, climate changes, rainforest clearing or air travel). However, the nutritional status of the host, until recently, has not been considered a contributing factor to the emergence of infectious disease. In this review, we show that host nutritional status can influence not only the host response to the pathogen, but can also influence the genetic make-up of the viral genome. This latter finding markedly changes our concept of host-pathogen interactions and creates a new paradigm for the study of such phenomena.</div>
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<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Beck, Melinda A" sort="Beck, Melinda A" uniqKey="Beck M" first="Melinda A" last="Beck">Melinda A. Beck</name>
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Serveur d'exploration SRAS

Host nutritional status: the neglected virulence factor.

Host nutritional status: the neglected virulence factor.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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